Publications

Aryl-Capped Lysine-Dehydroamino Acid Dipeptide Supergelators as Potential Drug Release Systems

Carlos Oliveira, Renato B. Pereira, David M. Pereira, Hilliou, L., Tarsila G. Castro, José A. Martins, Peter J. Jervis, Paula M.T. Ferreira.

International Journal of Molecular Sciences, 2022, 23, 11811.

Plasmonic lipogels: driving co-assembly of composites with peptide-based gels for controlled drug release

Veloso, Sérgio; Gomes, Valéria; Mendes, Sérgio; Hilliou, Loic; Pereira, Renato; Pereira, David; Coutinho, Paulo; Ferreira, Paula; Correa-Duarte, Miguel Angel; Castanheira, E.

Soft Matter, in press

Discovery of Novel Halogenated Coelenteramines with Tumor-Selective Anticancer Activity for Lung and Gastric Cancer

Patricia González-Berdullas, Renato B. Pereira, Cláudia Teixeira, José Pedro Silva, Carla M. Magalhães, José E. Rodríguez-Borges, David M. Pereira*, Joaquim C.G. Esteves da Silva, Luís Pinto da Silva.

International Journal of Molecular Sciences, 2022, 23, 8271.

A pipeline for natural small molecule inhibitors of endoplasmic reticulum stress.

Daniela Correia da Silva, Patrícia Valentão, Paula B. Andrade, David M. Pereira*.

Frontiers in Pharmacology, 2022, https://doi.org/10.3389/fphar.2022.956154

Synthesis, computational and nanoencapsulation studies on eugenol-derived insecticides.

Catarina M. M. Coelho, Renato B. Pereira, Tatiana F. Vieira, Cláudia M. Teixeira, Maria José G. Fernandes, Ana Rita O. Rodrigues, David M. Pereira, Sérgio F. Sousa, A. Gil Fortes, Elisabete M. S. Castanheira.

New Journal of Chemistry, 2022, 46, 14375-14387

Valorisation of the industrial waste of Chukrasia tabularis A.Juss.: Characterization of the leaves phenolic constituents and antidiabetic-like effects

Catarina Andrade, Federico Ferreres, Nelson G. M. Gomes, Angel Gil-Izquierdo, Sutsawat Duangsrisai, David M. Pereira, Paula B. Andrade, Patrícia Valentão.

Industrial Crops & Products, 2022, 185, 115100.

An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentration – prepared from a known folate receptor ligand

Carlos Oliveira, Sérgio R. S. Veloso, Elisabete M. S. Castanheira, Pedro R. Figueiredo, Alexandra T.P. Carvalho, Loic Hilliou, David M. Pereira, Renato B. Pereira, José A. Martins, Paula M. T. Ferreira, Peter J. Jervis.

Soft Matter, 2022, 18, 1955-1966.

Eugenol β-amino/β-alkoxy alcohols with selective anticancer activity

Cláudia Teixeira, Renato B. Pereira, N. F. S. Pinto, Catarina M. M. Coelho, Maria José G. Fernandes, A. Gil Fortes, M. Sameiro T. Gonçalves, David M. Pereira*.

International Journal of Molecular Sciences, 2022, 23, 3759.

HPLC-DAD-ESI/MSⁿ and UHPLC-ESI/QTOF/MSⁿ characterization of polyphenols in the leaves of Neocarya macrophylla (Sabine) Prance ex F. White and cytotoxicity to gastric carcinoma cells.

Vera Ribeiro, Federico Ferreres, Andreia P. Oliveira, Nelson G. M. Gomes, Ángel Gil-Izquierdo, Luísa Araújo, David M. Pereira, Paula B. Andrade, Patrícia Valentão.

Food Research International, 2022, 155, 111082

Assessment of the free radical scavenging potential of cannabidiol under physiological conditions: theoretical and experimental investigations

Houssem Boublebd, David M. Pereira; Imene Amine Khodja; Nguyen Thi Hoa; Adam Mechler; Quan V. Vo.

Journal of Molecular Liquids, 2022, 346, 118277

ER stress in obesity pathogenesis and management

Amir Ajoolabady, Daniel J. Klionsky, Simin Liu, Gregory Y.H. Lip, Simon Barquera, Jaakko Tuomilehto, Sina Kavalakatt, Afshin Samali, David M. Pereira, Jun Ren.

Trends in Pharmacological Sciences, 2022, 43, 97-109.

Amino Alcohols from Eugenol as Potential Semisynthetic Insecticides: Chemical, Biological, and Computational Insights

Renato B. Pereira, Nuno F. S. Pinto, Maria José G. Fernandes, Tatiana F. Vieira, Ana Rita O. Rodrigues, David M. Pereira, Sérgio F. Sousa, Elisabete M. S. Castanheira, A. Gil Fortes, M. Sameiro T. Gonçalves

Molecules, 2021, 26, 6616.

Amino Alcohols from Eugenol as Potential Semisynthetic Insecticides: Chemical, Biological, and Computational Insights

Renato B. Pereira, Nuno F. S. Pinto, Maria José G. Fernandes, Tatiana F. Vieira, Ana Rita O. Rodrigues, David M. Pereira, Sérgio F. Sousa, Elisabete M. S. Castanheira, A. Gil Fortes, M. Sameiro T. Gonçalves

Molecules, 2021, 26, 6616.

Unravelling data for rapid evidence- based response to COVID-19: a summary of the unCoVer protocol

José L. Peñalvo,Elly Mertens, Enisa Ademović,  Seval Akgun, Ana Lúcia Baltazar, Dora Buonfrate, Miran Čoklo, Brecht Devleesschauwer, Paula Andrea Diaz Valencia, João C. Fernandes, Enrique Javier Gómez, Paul Hynds, Zubair Kabir, Jörn Klein, Polychronis Kostoulas, Lucía Llanos Jiménez, Lucia Maria Lotrean, Marek Majdan, Ernestina Menasalvas, Paul Nguewa,  In-Hwan Oh, Georgie O’Sullivan, David M. Pereira, Miguel Reina Ortiz, Silvia Riva, Gloria Soriano, Joan B. Soriano, Fernando Spilki, Mary Elizabeth Tamang, Antigona Carmen Trofor, Michel Vaillant, Sabrina Van Ierssel, Jakov Vuković, José M. Castellano.

BMJ Open 2021;11:e055630

New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation

Carolina M. Natal, Maria José G. Fernandes, Renato B. Pereira, David M. Pereira, A. Gil Fortes, Elisabete M. S. Castanheira, M. Sameiro T. Gonçalves.

RSC Advances, 2021, 11, 34024-34035

 Preliminary studies of microencapsulation and anticancer activity of polyphenols extract from Punica granatum peels

Faezeh Fathi, Samad N. Ebrahimi, David Pereira, Berta N. Estevinho, Fernando Rocha.

The Canadian Journal of Chemical Engineering, 2021

Homarine alkyl esters derivatives as new promising acetylcholinesterase inhibitors

Karen G. João, Romeu A. Videira, Patrícia Valentão, David M. Pereira, Fátima Paiva-Martins, Paula B. Andrade.

ChemMedChem, 2021, 16, 3315-3325.

Bolaamphiphilic bis-dehydropeptide hydrogels as potential drug release systems.

Carolina Amorim, Sérgio R.S. Veloso, Elisabete M.S. Castanheira, Loic Hilliou, Renato B. Pereira, David M. Pereira, José A. Martins, Peter J. Jervis, Paula M. T. Ferreira.

Gels, 2021, 7, 52.

Evaluation of a Model Photo-Caged Dehydropeptide as a Stimuli-Responsive Supermolecular Hydrogel.

Peter J. Jervis, Loic Hilliou, Renato B. Pereira, David M. Pereira, José A. Martins, Paula M. T. Ferreira.

Nanomaterials, 2021, 11, 704.

Essential oils in livestock: From health to food quality. 

Ralph Nehme, Sonia Andrés, Renato B. Pereira, Meriem Ben Jemaa, Saïd Bouhallab, Fabrizio Ceciliani, Secundino López, Fatma Zohra Rahali, Riadh Ksouri, David Pereira, Latifa Abdennebi-Najar.

Antioxidants, 2021, 10, 330.

Activation of caspase-3 in gastric adenocarcinoma AGS cells by Xylopia aethiopica (Dunal) A. Rich. fruit and characterization of its phenolic fingerprint by HPLC-DAD ESI(Ion Trap)-MSn and UPLC-ESI-QTOF-MS2. Food Research International

Vera Ribeiro, Federico Ferreres, Tiago Macedo, Ángel Gil-Izquierdo, Andreia P. Oliveira, Nelson G. M. Gomes, Luísa Araújo, David M. Pereira, Paula B. Andrade, Patrícia Valentão.

Food Research International, 2021, 141, 110121

Supramolecular ultra-short carboxybenzyl-protected dehydropeptide-based hydrogels for drug delivery.

Sérgio R. S. Veloso, Peter J. Jervis, Joana F. G. Silva, Loic Hilliou, C. Moura, David M. Pereira, Paulo J. G. Coutinho, J. A. Martins, Elisabete M. S. Castanheira, and Paula M. T. Ferreira

Materials Science & Engineering C, 2021. in press

Cassia sieberiana DC. leaves modulate LPS-induced inflammatory response in THP-1 cells and inhibit eicosanoid-metabolizing enzymes.

Tiago Macedo, Federico Ferreres, David M. Pereira, Andreia P. Oliveira, Nelson G. M. Gomes, Ángel Gil-Izquierdo, Patrícia Valentão, Luísa Araújo, Paula B. Andrade.

Ethnopharmacology, 2021, 269, 113746.

Absolute configuration by vibrational circular dichroism of anti-inflammatory macrolide briarane diterpenoids from the Gorgonian Briareum asbestinum.

Dawrin Pech-Puch, Pedro Joseph-Nathan, Carlos González-Salas, Diana Martínez-Matamoros, David M. Pereira, Renato Pereira, Carlos Jiménez, and Jaime Rodríguez.

Scientific Reports, 2021, 11, 496.

Valorisation of kitul, an overlooked food plant: phenolic profiling of fruits and inflorescences and assessment of their effects on diabetes-related targets.

Ferreres, F., Andrade, C., Gomes, N., Andrade, P., Gil-Izquierdo, A., Pereira, D.M., Suksungworn, R., Duangsrisai, S., Videira, R., Valentão, P.

Food Chemistry, 2021, 342, 128323.

Cytotoxic plant extracts towards insect cells: bioactivity and nanoencapsulation studies for application as biopesticides

Ana I. F. Lopes, Mariana Monteiro, Rita L. Araújo, A. Rita O. Rodrigues, Elisabete M. S. Castanheira, David M. Pereira, Pedro Olim, A. Gil Fortes, M. Sameiro T. Gonçalves.

Molecules, 2020, 25, 5855

Gustavia gracillima Miers. flowers effects on enzymatic targets underlying metabolic disorders and characterization of its polyphenolic content by HPLC-DAD-ESI/MSn. 

Catarina Andrade, Federico Ferreres, Nelson G. M. Gomes, Angel Gil-Izquierdo, Sutsawat Duangsrisai, David M. Pereira, Paula B. Andrade, Patrícia Valentão.

Food Research International, 2020, 137, 109694.

New eugenol derivatives with enhanced insecticidal activity

Maria José G. Fernandes, David M. Pereira*, Renato B. Pereira, A. Gil Fortes, Elisabete M. S. Castanheira, M. Sameiro T. Gonçalves.

International Journal of Molecular Sciences, 2020, 21, 9257

A review on medicinal plants in Thai Traditional Medicine for the treatment of diabetes mellitus: Ethnobotanical surveys, scientific evidence and phytochemicals.

Catarina Andrade, Nelson G. M. Gomes, Paula B. Andrade, David M. Pereira, Patrícia Valentão.

Journal of Ethnopharmacology, 2020, 263, 113177

Natural pigments of anthocyanin and betalain for coloring soybean yogurts.

Sandra Dias, Elisabete M. S. Castanheira, A. Gil Fortes, David M. Pereira, M. Sameiro T. Gonçalves.

Foods, 2020, 9, 10.3390/foods9060771

Echium plantagineum L. honey: search of pyrrolizidine alkaloids and polyphenols, anti-inflammatory potential and cytotoxicity.

Rute Moreira, Fátima Fernandes, Patrícia Valentão, David M. Pereira*, Paula B. Andrade.

Food Chemistry, 2020, 328, 127169

An efficient isolation platform for obtaining astaxanthin monoesters from the microalgae Haematococcus pluvialis using high performance countercurrent chromatography (HPCCC).

Tereza Fábryová, Lenka Tumova, Daniela Silva, David M. Pereira, Paula Andrade, Patricia Valentao, Pavel Hrouzek, Jiří Kopecký

Algal Research, 2020,

Application of natural pigments in ordernary cooked ham.

Sandra Dias, Elisabete M. S. Castanheira, A. Gil Fortes, David M. Pereira, A. Rita O. Rodrigues, Regina Pereira, M. Sameiro T. Gonçalves.

Molecules, 2020, 25, 2241.

Endoplasmic reticulum stress signaling in cancer and neurodegenerative disorders: Tools and strategies to understand its complexity.

Daniela Correia da Silva, Patrícia Valentão, Paula B. Andrade, David M. Pereira*.

Pharmacological Research, 2020, 155, 104702.

Chalcone-type Compounds and 2-Pyrazoline Derivatives Bearing an Imidazole Moiety: Synthesis and caspase-dependent anticancer activity.

Chouiter, I.; Boulebd, H.; Pereira, D. M.*; Valentão, P.; Andrade, P.; Belfaitah, A.; Silva, A.

Future Medicinal Chemistry, 2020, https://doi.org/10.4155/fmc-2019-0342

Biological Evaluation of Naproxen–Dehydrodipeptide Conjugates with Self-Hydrogelation Capacity as Dual LOX/COX Inhibitors

Rute Moreira, Peter J. Jervis, André Carvalho, Paula M. T. Ferreira, José A. Martins, Patrícia Valentão, Paula B. Andrade, David M. Pereira*.

Pharmaceutics, 2020, 12, 122.

Enhancement of phenolics content and anti-inflammatory properties of grape pomace extracts as a consequence of treatment with Trametes versicolor.

Ana Bucić-Kojić, Fátima Fernandes, Tânia Silva, Mirela Planinić, Marina Tišma, Gordana Šelo, Darijo Šibalić, David M. Pereira, Paula B. Andrade.

Food & Function, 2020, 11, 680-688.

Dehydropeptide-based plasmonic magnetogels: a supramolecular composite nanosystem for multimodal cancer therapy.

Veloso, S., Martins, J., Hilliou, L., Amorim, C. O., Vitor, A., Bernardo, A., Jervis, P., Moreira, R., Pereira, D. M., Coutinho, P., Ferreira, P., Castanheira, E.

Journal of Materials Chemistry B. 2020, 8, 45.

Anti-inflammatory properties of Xylopia aethiopica leaves: Interference with pro-inflammatory cytokines in THP-1 derived macrophages and flavonoid profiling.

Macedo, T., Ribeiro, V., Oliveira, A., Pereira, D.M.,  Fernandes, F., Gomes, N.G.M., Araújo, L., Valentao, P., Andrade, P.B.

Journal of Ethnopharmacology, 2020, 248, 112312.

Phenolic profiling and biological potential of Ficus curtipes Corner leaves and stem bark: 5-lipoxygenase inhibition and interference with NO levels in LPS-stimulated RAW 264.7 macrophages.

Catarina Andrade, Federico Ferreres, Nelson Gomes, Sutsawat Duangsrisai, Nattawut Srisombat, Srunya Vajrodaya, David Pereira, Angel Gil-Izquierdo, Paula Andrade, Patrícia Valentão.

Biomolecules, 2019, 22, E400.

Flavonoid composition of Salacia senegalensis (Lam.) DC leaves, evaluation of antidermatophytic effects, and potential amelioration of the associated inflammatory response.

Nelson G. M. Gomes, Andreia P. Oliveira, Diana Cunha, David M. Pereira, Patrícia Valentão, Eugénia Pinto, Luísa Araújo, Paula B. Andrade.

Molecules, 2019, 24, E2530.

Benzoquinones from Cyperus spp. trigger IRE1α-independent and PERK-dependent ER stress in human stomach cancer cells and are novel proteasome inhibitors.

Vera Ribeiro, Paula B. Andrade, Patrícia Valentão, David M. Pereira*.

Phytomedicine, 2019, 63, 153017.

Anti-inflammatory effects of 5α,8α-epidioxycholest-6-en-3β-ol, a steroidal endoperoxide isolated from Aplysia depilans through bioguided fractionation.

Renato B. Pereira, David M. Pereira*, Carlos Jiménez, Romeu Videira, Olga Silva, Paula B. Andrade, Patrícia Valentão.

Marine Drugs, 2019, 17, 330.

Marine-derived Chemotherapeutic Pipeline: Clinical Benefits and Scientific Gains.

Renato B. Pereira, Ramesh Dasari, Florence Lefranc, Patrícia Valentão, Alexander Kornienko, David M. Pereira, Paula B. Andrade, Nelson G.M. Gomes.

Marine Drugs, 2019, 17, 329.

Novel styrylpyrazole-glucosides and their dioxolo-bridged doppelgangers: synthesis and cytotoxicity.

Carreira, Ana; Pereira, David; Andrade, P.; Valentao, P.; Silva, Artur; Braga, Susana; Silva, Vera.

New Journal of Chemistry, 2019, 43, 8299-8310.

Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic applications.

André Carvalho, Juan Gallo, Patrícia Valentão, Paula B. Andrade, David M. Pereira, Loic Hilliou, Paula M.T. Ferreira, Manuel Bañobre-López, and José A. Martins.

Nanomaterials, 2019, 5, 541.

A new insight on elderberry anthocyanins bioactivity: modulation of mitochondrial redox chain functionality and cell redox state.

Dina Neves, Patrícia Valentão, João Bernardo, Maria C. Oliveira, Jorge M. G. Ferreira, David M. Pereira, Paula B. Andrade, Romeu A. Videira.

Journal of Functional Foods, 2019, 56, 145-155.

Hydrophilic carbon nanomaterials: characterization by physical, chemical and biological assays.

Veloso A. D., Ferraria A. M., Botelho de Rego A. M., Tavares P. B., Valentão P., Pereira D. M, Andrade P. B., Fernandes A. J., Oliveira M. C., Videira R. A.

ChemMedChem, 2019, 14, 699-671.

Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolated from Hypsiboas raniceps skin secretion.

Cláudia S. F. C. Popov, Beatriz Simas Magalhães, Brian James Goodfellow, Anamélia Lorenzetti Bocca, David M. Pereira, Paula B. Andrade, Patrícia Valentão, Pedro J. B. Pereira, Paulo H. de Holanda Veloso Júnior, Everaldo Gonçalves de Barros,Taia M. B. Rezende.

Peptides, 2019, 2, 11-21.

Measuring progress and projecting attainment of the health-related Sustainable Development Goals in 195 countries and territories: an analysis from the Global Burden of Disease Study 2017.

The Lancet, 2018, 392, 2091-2138.

Edible seaweeds’ phlorotannins in allergy: A natural multi-target approach.

Barbosa, M., Lopes, G., Valentão, P., Ferreres, F., Gil-Izquierdo, A., Pereira, D. M., Andrade, P. B.

Food Chemistry, 2018, 265, 233-241.

Trace elements in edible Aplysia species: relationship with the desaturation-elongation indexes of fatty acids.

Pereira, R. B., Almeida, A., Pereira, D. M., Silva, O., Andrade, P.B., Pinto, E., Valentão, P.

Chemosphere, 2018, 208, 682-690.

Pyrrolizidine alkaloids: chemistry, pharmacology and toxicology.

Moreira, R., Pereira, D. M*, Valentão, P., Andrade, P. B.

International Journal of Molecular Sciences, 2018, 19, E1668.

Leaves and stem bark from Allophylus africanus P. Beauv.: An approach to anti-inflammatory properties and characterization of their flavonoid profile.

Ferreres, F., Gomes, N., Valentão, P., Pereira, D. M., Gil-Izquierdo, A., Araújo, L., Silva, T., Andrade, P. B.

Food and Chemical Toxicology, 2018, 118, 430-438.

Chemical profiling of edible seaweed (Ochrophyta) extracts and assessment of their in vitro effects on cell-free enzyme systems and on the viability of glutamate-injured SH-SY5Y cells.

Fernandes, F., Barbosa, M., Pereira, D. M., Sousa-Pinto, I., Valentão, P., Azevedo, I. C., Andrade, P. B.

Food and Chemical Toxicology, 2018, 116, 196-206.

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer`s disease-like pathology.

Mendes, D., Moreira, P., Oliveira, M. M., Coutinho, J., Nunes, F., Pereira, D. M., Valentao, P., Andrade, P. B., Videira, R.

The Journal of Nutritional Biochemistry. 2018, 55, 165-177.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Nomenclature Committee on Cell Death Collaborators

Cell Death & Differentiation, 2018, 25, 486-54.

Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones.

David M. Pereira*, Patrícia Valentão, Paula B. Andrade.

Chemical Science, 2018, 9, 1740-1752.

Toxicity and SAR of α,β-dehydroamino acids against human cancer cell lines.

Videira, R. A., Andrade, P. B., Monteiro, L. S., Valentão, P., Ferreira, P. M. T., Pereira, D. M.*

Toxicology in Vitro, 2018, 47, 26-37.

Profiling phlorotannins from Fucus spp. of the Northern Portuguese coastline: chemical approach by HPLC-DAD-ESI/MSⁿ and UPLC-ESI-QTOF/MS.

Lopes, G., Barbosa, M., Allejo, F., Gil-Izquierdo, A., Andrade, P. B., Valentão, P., Pereira, D. M., Ferreres, F.  

Algal Research, 2018, 29, 113-120.

Hybrid MS/NMR Methods on the Prioritization of Natural Products: Applications in Drug Discovery.

Gomes, N. G. M., Pereira, D. M., Valentão, P., Andrade, P. B.

Journal of Pharmaceutical and Biomedical Analysis, 2018, 147, 234-249.

Phlorotannin extracts from Fucales: marine polyphenols as bioregulators engaged in inflammation-related mediators and enzymes.

Barbosa, M., Lopes, G., Ferreres, F., Andrade, P. B., Pereira, D. M., Valentão, P.

Algal Research, 2017 28, 1-8.

Further insights on tomato plant by-products: antioxidant capacity and cytotoxicity of leaf extracts in human gastric cells.

Figueiredo-González, M., Valentão, P., Pereira, D. M., Andrade, P. B.

Food & Chemical Toxicology, 2017, 109, 386-392.

Synthesis and preliminary biological evaluation of new phenolic and catecholic dehydroamino acid derivatives.

Monteiro, L. S., Oliveira, S., Paiva-Martins, F., Ferreira, P. M. T, Pereira, D. M., Andrade, P. B., Valentão, P.

Tetrahedron, 2017, 73, 6199-6209.

UHPLC-MS/MS profiling of Aplysia depilans and assessment of its potential therapeutic use: interference on iNOS expression in LPS-stimulated RAW 264.7 macrophages and caspase-mediated pro-apoptotic effect on SH-SY5Y cells.

Renato B. Pereira, Diana C.G.A. Pinto, David M. Pereira, Nelson G.M. Gomes, Artur M.S. Silva, Paula B. Andrade, Patrícia Valentão.

Journal of Functional Foods, 2017, 37, 164-175.

Toxicity of phenolipids: Protocatechuic acid alkyl esters trigger disruption of mitochondrial membrane potential and caspase activation in macrophages.

David M. Pereira*, Tânia Silva, Sónia-Lousada Barreiro, Patrícia Valentão, Fátima Paiva-Martins, Paula B. Andrade.

Chemistry and Physics of Lipids, 2017, 206, 16-27.

Anti-Inflammatory Properties of the Stem Bark from the Herbal Drug Vitex peduncularis Wall. ex Schauer and Characterization of its Polyphenolic Profile.

Federico Ferreres, Sutsawat Duangsrisai, Nelson G. M. Gomes, Rungcharn Suksungworn, David M. Pereira, Angel Gil-Izquierdo, Patrícia Valentão, Kiattawee Choowongkomon, Paula B. Andrade.

Food & Chemical Toxicology, 2017, 106, 8-16.